Prediction of clinical cardiovascular events with carotid. Predictive value for cardiovascular events of common carotid intima. We invite you to download a 14day fully functional trial version of cardiovascular. The test measures the thickness of the inner two layers of the carotid arterythe intima and mediaand alerts physicians to any thickening when patients are still asymptomatic. Since there is no evidence demonstrating the relationship between dietary patterns and subclinical atherosclerosis in children and adolescents, we aimed to examine the association between dietary patterns and carotid intima media thickness cimt in children and adolescents with overweight and obesity.
Carotid intimamedia thickness test cimt cedarssinai. Predictive value for cardiovascular events of common. Abnormally increased carotid intima mediathickness and. The measurement is usually made by external ultrasound and occasionally by internal, invasive ultrasound catheters. Cimt has been frequently utilized in clinical trials to test the efficacy of cardiovascular drugs. The objective of this study was to assess if there is any correlation of duration and disease activity of rheumatoid arthritis with carotid intima media thickness cimt, an efficient. Jan 27, 2015 the commercially available semiautomatic intimamedia thickness measurement software math 3. Carotid intimamedia thickness cimt is probably the most commonly used marker for atherosclerotic disease as an alternative for cardiovascular morbidity and mortality. Careful evaluation of cimt studies reveals discrepancies in the comprehensiveness with which cimt is assessedthe number of carotid segments evaluated common carotid artery cca, internal carotid artery ica, or the carotid bulb, the type of measurements made mean or. Aims carotid intima media thickness cimt predicts cardiovascular cvd events, but the predictive value of cimt change is debated. So, what can we takeaway from these two studies looking at intima media thickness. Background the combined thickness of the intima and media of the carotid artery is associated with the prevalence of cardiovascular disease.
Growing evidence indicates that depressive disorders dds are an important risk factor for atherosclerosis. Measurements were performed on a ge vivid 3 ultrasound scanner. Reproducibility of aortic intimamedia thickness in. Recently, a newly developed software allows semiautomatic measurement of mean imt auto imt. To enhance diagnostic effectiveness, an ultrasound software tool has been developed that can measure the thickness of the intima media layers of the carotid artery, for assessing an asymptomatic patients risk of developing cardiovascular disease. The upper limit of normal for the mean carotid intima media thickness ranged from 0. Limited information is currently available about whether carotid intima media thickness imt correlates with the degree of disease activity in spondyloarthritis. Reference intervals for common carotid intimamedia thickness. Dec 12, 20 t1 ecgbased frame selection and curvaturebased roi detection for measuring carotid intima media thickness. Intimamedia thickness imt determined by bmode ultrasonography is comparable to the thickness of intimamedia complexes as determined by histologic examination. However, it is important to acknowledge that a positive effect of a drug on cimt is not necessarily translated into clinical benefit e. Carotid ultrasonography was performed by a mylab 70 scanner esaote.
The result of this injury can be severe and lifethreatening. The aim of this study was to evaluate the presence of common carotid artery cca intima media thickness imt and circulation inflammation markers in patients with dd. We have developed dicombased software that measures cimt. Intima media thickness imt, flowmediated dilation fmd of the brachial artery, and nitroglycerinemediated dilation. A suitable marker for atherosclerosis, however, should meet several criteria before it can be validly used. However, measurement of intimamedia thickness imt in the artery is. Intima media thickness imt has been proposed to be a morphological criterion of atherosclerosis. This study was conducted to examine the effects of age and gender on cimt and cutoff values for cimt in different age groups. At the heart of the system is computer software developed by nasas jet propulsion laboratory. Jun 12, 2008 the aim of this study was to evaluate the feasibility and accuracy of commercially available software directly implemented on the ultrasound scanner for automated measurement of the intima media thickness imt of the common carotid artery on source images. Carotid intimamedia thickness imt, an indicator of atherosclerosis and coronary heart disease chd. First, inter and intraobserver correlations were assessed for the. Common carotid artery intima media thickness ccimt is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease cvd.
Reference intervals for common carotid intimamedia. Details regarding the control and nonmorquio mps cohorts have been published 11, 12. Genoa, italy, equipped with 712 mhz linear transducer and the automated software guided technique radiofrequencyquality intima media thickness in realtime qimt, esaote, maastricht, holland. Increased coronary intima media thickness cimt has been associated with adverse cardiovascular outcomes, as have increased glucose levels. N2 carotid intima media thickness cimt measurement is a sensitive, and highly reproducible technique for cardiovascular risk stratification. Carotid intimamedia thickness and plaque in borderline. Adult carotid intimamedia thickness, dietary fats, and. Careful evaluation of cimt studies reveals discrepancies in the comprehensiveness with which cimt is assessedthe number of carotid segments evaluated common carotid artery cca, internal carotid artery ica, or the carotid bulb, the type of measurements made.
Design crosssectional study child health checkpoint, nested within a prospective cohort study, the longitudinal. Carotid intimamedia thickness cimt to assess drug efficacy. Measurement of the carotid intimamedia thickness enables arterial wall thickening to. The aim of this study was to determine cimt ris in a cohort of 1012 healthy subjects from argentina. Carotid intimamedia thickness cimt measured by bmode. Accordingly, several carotid intima media thickness measurements as well as plaque were related to established cardiovascular risk factors. The carotid intimamedia thickness test cimt is a measure used to diagnose the extent of carotid atherosclerotic vascular disease. We studied the associations between the thickness of the. Ashokkumar l1, rajendran p2 1department of computer science and engineering, k. A single measurement of cimt and plaque assessment improves predictions of risk of cardiovascular disease,1,2 and accaha guidelines3 support the use of cimt and plaque measurement for cardiovascular risk stratification with a class iia recommendation ie, evidence. The measurement of intimamedia thickness imt of large superficial arteries. Intima media thickness imt is widely measured for the evaluation of early atherosclerosis of the carotid artery. Objectives to describe a wellestablished marker of cardiovascular risk, carotid intimamedia thickness imt and related measures artery distensibility and elasticity in children aged 1112 years old and midlife adults, and examine associations within parentchild dyads.
Validation of an opensource tool for measuring carotid lumen. We aimed to 1 investigate the reproducibility of aimt in a populationderived cohort of infants. Extendedrelease niacin or ezetimibe and carotid intimamedia. Pdf carotid intimamedia thickness measurement through. Intimamedia thickness of brachial artery, vascular. Currently, a new automated ultrasound software, based on radio frequency, called rfqimt technology,proved to be a useful method for assessing subclinical atherosclerosis with the measurement of the intima media thickness imt in carotid arteries. The test measures the thickness of the inner two layers of the carotid arterythe intima and media and alerts physicians to any. Carotid intima media thickness reference intervals for a. Original article from the new england journal of medicine extendedrelease niacin or ezetimibe and carotid intima media thickness nejm group. Intima media thickness imt determined by bmode ultrasonography is comparable to the thickness of intima media complexes as determined by histologic examination. Carotid intimamedia thickness cimt has been shown to predict cardiovascular cv risk in multiple large studies. Evaluation of a new carotid intimamedia thickness measurement.
Evaluation of carotid intimamedia thickness imt using. Intimamedia thickness segmentation using weighted graph. The association between carotid intima media thickness cimt and cardiovascular disease is well established. Intimamedia thickness of carotid artery and aortic pulse. Medline, embase, scopus, and cochrane databases were searched from inception through 2009 for original research reporting. Carotid artery intimamedia thickness, distensibility and. Dr bots reported receiving study grants for studies on carotid intima media thickness andor honoraria for professional input on carotid intima media thickness issues from astrazeneca, icelandic heart foundation, organon, pfizer, the netherlands heart foundation, the netherlands organisation for health research and development, servier, and.
Citeseerx intimamedia thickness of the common carotid. Carotidartery intima and media thickness as a risk factor. Carotid intimamedia thickness and plaque in cardiovascular. The association between common carotid intima media thickness and incident myocardial infarction and stroke was evaluated by use of a logistic regression model. Medline, embase, scopus, and cochrane databases were searched from inception through 2009 for original. This plugin helps in extracting the intima media thickness imt of the far wall of the common carotid artery from the. Carotid intima media thickness imt is as an indicator of atherosclerosis, and manual measurement of imt manual imt is the most applied method to assess atherosclerosis. Carotid intimamedia thickness cimt and carotid lumen diameter cld are strong indicators of cardiovascular event risk and stenosis severity, respectively. The aim of this study was to evaluate the feasibility and accuracy of commercially available software directly implemented on the ultrasound scanner for automated measurement of the intima media thickness imt of the common carotid artery on source images.
This study aimed to compare the feasibility and reproducibility of manual imt and auto imt measurement in. Carotid intimamedia thickness in subjects with no cardiovascular. The link has not been established between glucose and cimt. Relationship between blood glucose and carotid intima. Pdf carotid intimamedia thickness for atherosclerosis. Intimamedia thickness imt provides a surrogate end point of cardiovascular outcomes in. We performed this study to evaluate the feasibility and accuracy of the newly developed korean software ks for measurement of the carotid intima media thickness imt. Measurements of carotid intimamedia thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events. Prediction of clinical cardiovascular events with carotid intima. Cardiovascular risk factors and increased carotid intima. Measurements of carotid intima media thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events. Jcm free fulltext natural history of atherosclerosis. With modern ultrasound scanners, imt can be easily and quickly assessed in clinical routine as well as in clinical and epidemiological research.
Background and purpose in this study, we investigated intima media thickness and plaque occurrence in the carotid arteries of men with borderline hypertension compared with that in normotensive control subjects and investigated the relations of these variables to atherosclerotic risk factors methods using bmode ultrasonography, we compared carotid artery intima media thickness and plaque. Simply select your manager software from the list below and click on download. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Pdf measurement of the carotid intima, media and intima. Ecgbased frame selection and curvaturebased roi detection. Rangasamy college of technology, tiruchengode, tamil nadu, india 2department of computer science and engineering, knowledge institute of technology, salem, tamil nadu, india abstract. Carotid intima media thickness test a carotid intima media thickness test cimt is used to determine the extent of plaque buildup in the walls of the arteries supplying blood to the head. Reference intervals ris of carotid intima media thickness cimt from large healthy population are still lacking in latin america. Correlation of carotid intima media thickness with disease. Measurement of the abdominal aortic intima media thickness by external ultrasound is a noninvasive methodology for quantifying the extent and severity of early. Cca intima media thickness imt and circulation inflammation markers in patients with dd. The commercially available semiautomatic intima media thickness measurement software math 3.
We aimed to investigate the change of cimt in prediabetes and type2 dm patients compared to subjects with normal glucose metabolism ngm. Stiffness parameters, intimamedia thickness and early. Stiffness parameters, intima media thickness and early atherosclerosis in systemic lupus erythematosus patients show all authors. Carotid intimamedia thickness and circulation markers of. Determination of intima media thickness of common carotid artery was performed with hewlett packard sonos 5 500, using automated computer software medicasoft. Analyses were performed with common carotid intima media thickness used as a continuous variable per sd and as a categorized variable based on quintile cutoff points of the. Association of dietary pattern with carotid intima media. Mean common carotid intima media thickness ccimt in relation to the number of risk factors rfs ie, body mass index, systolic blood pressure, triglyceride level, and lowdensity lipoprotein cholesterol level present, by sex. Is intimamedia thickness a predictor for cardiovascular. We assessed the relation between cimt change and events in individuals at high cardiovascular risk. Carotid averimt measurement using the new intimascope software may provide a more precise and.
Atherosclerosis is the major cause of the morbidity and mortality in type 1 diabetes mellitus dm. Carotid intima media thickness and its relations with the complications in patients with type 1 diabetes mellitus tip 1 diyabetes mellituslu hastalarda karotis intima media kal. The difference in intima media thickness between diabetics and controls and between hypertensive patients and controls, adjusted for age, was 0. Carotid intima media thickness cimt was one of the first available methods to display the atherosclerotic lesion and is commonly used in clinical trials as an endpoint thoenes et al. Mannheim carotid intimamedia thickness and plaque consensus. Methods and results from 31 cohorts with two cimt scans total n 89070 on average 3. Physical manifestations of atherosclerosis may begin in early life, particularly in the abdominal aorta. Article information, pdf download for intimamedia thickness.
Comparison between carotid plaque and carotid intimamedia. The automated softwareguided ultrasound assessment of. Measurements of carotid intima media thickness in non. The interpretation of ccimt values has been hampered by the absence of reference values, however. Carotid intima media thickness cimt increases in patients with adult type2 diabetes mellitus dm and is used for early detection of macrovascular complications.
Rheumatoid arthritis ra patients have a higher chance of adverse cardiovascular events due to accelerated atherosclerosis. A method for determining the intima media thickness of the near andor far wall of a blood vessel according to claim 1, including inputting into the computer a database of the intima media thickness, and possibly the presence of plaque combined with patient information consisting of some or all, but not limited to, age, gender, typical. The commercially available semiautomatic intimamedia thickness measurement software math 3. Carotid intimamedia thickness values are significantly high.
The authors performed a randomized controlled trial and noted that when the dietary distribution of fats met the recommended intake, there was a reduction in aortic intima media thickness and greater aortic distensibility. Carotid intimamedial thickness measured on multiple ultrasound. The carotid intima media thickness was assessed in 8 subjects 64 men and 74 women aged 2079 years whose age and sex were homogeneously distributed. Relationship between blood glucose and carotid intima media. Evaluation of a new carotid intimamedia thickness measurement by bmode ultrasonography using an innovative measurement software, intimascope. Usefulness of the semiautomated edgedetection software. Carotid intimamedia thickness and cardiovascular events. Reproducibility of aortic intimamedia thickness in infants. Carotid intima media thickness imt is a cvd risk factor, thus the aim of the study was to determine if an association between dietary p, especially food additive phosphate fap, intake, and imt exists. The objective of this study was to evaluate the correlation between articular and carotid ultrasound data and laboratory and clinical variables in patients with.
Assessment of intimamedia thickness of carotid arteries. Biochemistry parameters were examined by routine methods. However, the accuracy of imt measurement depends on technical skill and the mechanical resolution of each ultrasonographic device. Us6817982b2 method, apparatus, and product for accurately. Carotid intimamedia thickness and its relations with the. The morquio a cohort n 12 was 58% male and 42% female table 1. Ultrasound software tool measures carotid intimamedia thickness. Carotid intima media thickness measurement through semiautomated detection software and analysis of vascular walls. The national cholesterol education program adult treatment panel iii identified imt as a method to. Common carotid intimamedia thickness and risk of stroke and. Evaluation of a new carotid intimamedia thickness measurement by. We observed an increase in intima media thickness of 0. The current study aims to check the relationship between parameters derived from brachial blood pressure, the carotid artery intima media thickness imt, pulse wave velocity pwv and mean. Aortic intima media thickness measured by transabdominal ultrasound aimt is an intermediate phenotype of cardiovascular risk.
Mar 17, 2020 morquio a carotid intima media thickness. The carotid intima media thickness imt is a widely used surrogate marker for atherosclerosis worldwide. Measurements of carotid intima media thickness in noninvasive. Intima media thickness imt is a marker of subclinical atherosclerosis asymptomatic organ damage and should be evaluated in every asymptomatic adult or hypertensive patient at moderate risk for cardiovascular disease.
The purpose of this study was to investigate the interobserver variability of manual and also of computer software measurements of imt. A total of 60 hypercholesterolemic patients were enrolled. The cimt was determined as the average of three measurements in each common. Intima media thickness segmentation using weighted graph based active contour technique. Effect of rosuvastatin on progression of carotid intimamedia. Background and purpose in this study, we investigated intima media thickness and plaque occurrence in the carotid arteries of men with borderline hypertension compared with that in normotensive con. The current study aims to check the relationship between parameters derived from brachial blood pressure, the carotid artery intima media thickness imt, pulse wave velocity pwv and. We evaluated if ris for males and females and for left and right carotids were necessary. Automated measurement of intimamedia thickness of carotid. There are a few studies demonstrating an increase in intima media thickness imt of the common carotid artery cca after radiotherapy, especially in head and neck cancers. Background carotid intimamedia thickness imt is increasingly used as a. The interactive opensource software described here, cimtool, is based on active contours for measuring these indicators in clinical practice and thus helping in preventive diagnosis.
Intimal thickening is one of the first signs of atherosclerosis and can be measured with cimt. Carotid intima media thickness imt is increasingly used as a surrogate and intermediate end point of early atherosclerosis. Intimamedia thickness imt, also called intimal medial thickness, is a measurement of the thickness of tunica intima and tunica media, the innermost two layers of the wall of an artery. The effect of radioiodine on the intima media thickness of. Carotid intimamedia thickness in diabetics and hypertensive. Extendedrelease niacin or ezetimibe and carotid intima. Spectral doppler and automated softwareguided ultrasound. If a cimt shows increased thickness in the inner layers of the carotid artery, you may be at risk for cardiovascular disease.
Intimamedia thickness an overview sciencedirect topics. Carotid intimamedia thickness cimt was one of the first available methods to display the atherosclerotic lesion and is commonly used in clinical trials as an endpoint thoenes et al. The final step in the analysis is the automatic transfer of these results into a mysql database. Ultrasound software tool measures carotid intimamedia. Original article from the new england journal of medicine extendedrelease niacin or ezetimibe and carotid intimamedia thickness nejm group.
1443 383 389 1281 719 464 1576 424 1159 919 289 1195 136 378 1114 901 244 456 1193 257 1025 241 1347 1396 1148 451 208 138 899 572 1325 1196 370 359 86